Sentence examples for short-range target from inspiring English sources

Accumulation of these forms close to the source of production turns on short-range target genes.

The first is poorly mobile and activates short-range target genes.

Expression of Wg alone in this manner resulted in ectopic activation of the short-range target Sens.

Nodal signaling induces a gradient of activated Smad2, which induces long- and short-range target gene expression.

In contrast, reggie-1−/− discs had normal expression of the short-range target Sens; reggie-1 RNAi also did not prevent Sens expression (Supplementary Figure S9).

We next examined the Wg short-range target Senseless (Sens), which was reduced in opm-depleted cells leading to adult wing margin defects that phenocopy a loss of Wg function (Fig 4A,B).

For example, overexpression of reggie-1 led to reduction of the Wg short-range targets but expanded the Hh short-range targets.

Thus, provided that Wg is in excess, its enhanced mobility does not lead to loss of the short-range targets.

Erosion of the Wg gradient resulted in reduction of the short-range targets requiring high levels of Wg, whereas long-range targets were normal or even upregulated.

In contrast, short-range targets are not affected by loss of reggie-1, unless a concomitant reduction in Wg levels is performed.

Indeed, modelling predicts that broadening of the Wg production zone threefold, with a subsequent fivefold increase in the diffusion coefficient D, will result not in a reduction, but broadening of the short-range targets; a reciprocal narrowing of the Hh production zone with a concomitant increase of the diffusion coefficient predicts a Wg-like behaviour and reduction in the short-range targets.