The KAF provides a simple update of the parameter vector on a sample-by-sample basis; the error description length can be estimated from the short-term sequence of the local error, but we have to estimate appropriately the error sequence probability.
In the short term, targeted sequence analysis of several ORFs, including those that more closely cluster with that of the concatenated conserved ORF sequences, will provide a more accurate estimate of phylogenetic relationships rather than analysis of 1 ORF such as B646L.
Remaining 'moderate risk' alleles will be found within the short term by exome sequencing and extended GWAS studies will identify additional lower risk alleles.
To the best of our knowledge, no studies reporting genome sequence changes during short term acute infections have been reported for any bacterial pathogen.
The generation of microbial sequence data for "short term" patient management will revolutionize infectiology and diagnostic microbiology, allowing for deeper and more rapid insights into the patients' infectious pathologies [ 90].
Despite the rapid advances in sequencing technologies, the enormous size of Allium nuclear genomes will preclude full sequencing in the short term.
Whether this sequence of events occurs in short term caloric restriction needs to be investigated.
