Exact(8)
One interesting exception was a very short construct (amino acids 735 759) that corresponds precisely the linear bipartite NLS peptide motif alone, the minimal set of amino acids for importin binding [27].
In the current series we used a short construct design in order to reduce the stress on the terminal screws.
The short construct in detergent at low pH has a loose hairpin structure with noninteracting NHR and CHR helices which lie on the micelle surface.
Tublong, in addition to the short construct, contains the long helix (helix α9 in Rap1GAP) with the conserved Arg1743 (R388 in Rap1GAP), which in the Rap Rap1GAP system contributes to complex association (see above).
We developed a system that can be used in the treatment of diseases in the lumbar region (short construct) as well as the 3-dimensial corrections of scoliotic deformities [ 13].
Four patients had 1-level hemicorpectomy using a minimally invasive expandable tubular retractor system (X-TUBE, METRX, Medtronic, USA) with a short construct instrumentation using Longitude FNS system (Medtronic, USA) augmented with a screw on the index level contralateral to the corpectomy approach and polymethyl methacrylate (PMMA) was injected to through all screws and 1(f)).
Similar(52)
Binding of c-di-GMP enhanced interaction of a shorter construct of STING CTD (residues 139 344) with TBK1.
The shorter construct results in a signal of higher SNR and slower folding/unfolding kinetics, thereby facilitating the detection of otherwise fast structural transitions.
However, a slightly shorter construct (535 700) yielded crystals in a tetragonal space group that proved amenable to structure determination.
The shortest construct (−1768/+38Luc) displayed a low but yet detectable activity in endothelial cells, corresponding to a 93% loss of that in −8409/+38Luc but still with an endothelial/fibroblast ratio of 3.4.
MiR-485-5p MiR-485-5p MiR-485-5p MiR-485-5perase activity toverexpressionIF3α-shoreducedthect in the SW872 celuciferase
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