Both proximal-to-distal and distal-to-proximal polyadenylation shifts in genes were validated by q-PCR or shown as wiggle plots.
Older mines that were "validated" went forth.
Positive results were validated.
Prior to assessing the VLS results on the eight protein test set, the thermal shift methodology was validated on three proteins having known binding and nonbinding ligands.
The relationship between positive selection and protein functional shift has been validated biochemically through the rational mutagenesis of various fungal, plant and mammal enzymes [ 21- 24].
The test data is highly agreeable to the simulation data and the effectiveness of shift control strategies is validated by the comparison between simulation results and the test data.
Shift has also been validated and verified against various reactor physics benchmarks, including the Consortium for Advanced Simulation of Light Water Reactors Virtual Environment for Reactor Analysiss criticality test suite and several Westinghouse AP1000® problems presented in this paper.
One advantage of complementing the 1D pure shift spectrum with the 2D spectrum is that no signals corresponding to the weak sidebands in the 1D spectrum appear in the 2D, allowing real pure shift signals to be validated if needed by simple comparison.
The desired shift towards the lower frequency is validated although the silencer performance is still less than ideal due to both parametric and operational constraints of the rig.
