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Maybe this wide effect shifts the effect of morphine on presynaptic glutamate release in VTA-DA neurons toward an inhibitory effect.
10 A recent editorial proposed that repeated bouts of sustained and/or high-intensity aerobic exercise, such as that required for marathon training and competition, evokes systemic vascular remodelling that shifts the effect of aerobic exercise from cardioprotective to atherogenic.
If substrate levels, or PS1 isoform contributes to in vivo potency shifts, the effect could potentially confound estimates of in vivo selectivity in an APP and/or PS1FAD transgene mouse model.
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The application of combinations may reduce costs, and importantly shift the effect of the drug towards fungicidal activity (for review see [ 17]).
In scenario b), we shifted the effect in design 1 6 analogously to scenario a) by δ=5 from the rest of the network.
Those authors demonstrated that the addition of comorbidities as confounders to the regression model shifted the effect estimate away from 1.0, which indicates correction for confounding by indication.
Publication bias was assessed using the Orwin fail-safe N. The Orwin fail safe N estimates the number of unpublished studies that would be required to shift the effect size towards a null result [ 32].
The changes observed in the labour market status of mothers between 2008 and 2014 appear to have shifted the effects on the probability of full vaccination of children.
Dandona et al. noted that increased concentrations of TNFα and IL-6 in type 2 diabetes may modulate insulin action by suppressing insulin signal transduction and this may "shift" the effects of insulin to favor a more proinflammatory state [ 48].
The Obi1 compound shifts the pressure-effect curve leftward and removes inactivation.
The second view, devaluation, shifts the cause and effect.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com