In contrast, truncation by DP4 inactivates CCL2 leading to a shift to higher concentrations needed to elicit chemotaxis (Fig 3 of Supporting Information).
According to Lima [ 43], the addition of predation risk to an already risky situation (no cover and weasel odour in our case) should not cause prey to use time for predator scanning but rather to shift to a concentration of foraging investment.
Increasing the dose of the artemisinin component in ACT might partly overcome decreased sensitivity, in case the concentration-effect relationship has merely shifted to higher concentrations in this parasite population.
When segments were subjected to increasing K+ concentrations in the presence of levcromakalim, BAY K8644, or their combination, levcromakalim shifted the curve to higher K+ concentrations (+5.93 ± 0.87 mM), whereas BAY K8644 caused a shift to lower K+ concentrations (-7.98 ± 1.09 mM).
In this way we addressed the question whether the observed epistatic interaction at 175 mM NaCl holds true over a wide range of NaCl concentrations or results from additive effects where the inhibition curves of the different genotypes gradually shift to higher NaCl concentrations but still germinate almost 100% at 175 mM.
The unfolding transition monitored by CD spectroscopy was responsive to tyrosine and ATP resulting in a shift to higher denaturant concentrations in the presence of these ligands.
The simultaneously released pAB anions were found to exhibit the envisioned inhibiting effect and caused corrosion initiation of the steel to shift to higher chloride concentrations than without the modified hydrotalcites.
The concentration inhibition curve for hetL164P showed a striking shift to higher ATP concentrations, with an IC50 of about 100 μmol/l, and a marked pedestal of unblocked current at very high ATP concentrations.
Depending on the size and number of rods, some of the chains studied exhibit a biphasic region at equilibrium that shifts to lower concentrations with increasing flow.
In RT112 cells, the pattern was similar, but shifted to lower concentrations.
