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At these physiological metal concentrations, the concentration of Mn+2 is not large enough to shift the equilibrium of binding in the direction of metal-phosphate complex formation.
The absence of these residues may shift the equilibrium of 8-oxoG from anti to syn in the Polκ active site.
This sequestration of tubulin from the subunit pool would be expected to shift the equilibrium of free to polymerized tubulin to disfavor assembly.
Indeed, in an instructive article, Schellman [9] made a quantitative evaluation of Le Chatelier's principle that indicates that for example, the binding of ligands to a dimer will shift the equilibrium of the association reaction toward the dimer; conversely, ligand binding to one of the intermediate species in dimer formation will affect adversely the formation of the dimer.
It appears that disruption of the FABD helix-4 can shift the equilibrium of the kinase N-lobe towards those conformations that do not bind imatinib and thus causing imatinib resistance through a mechanism that also requires the sequences surrounding the NLS2 and the NLS-3 region (aa-612 to aa-774).
For a typical case of protein denaturation, pressure will shift the equilibrium of the reactants (PN + nH2O) into the products (PD H2O) n ), where PN and PD are native and denatured proteins, respectively.
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It wouldn't have been enough to win but he believed it might have shifted the equilibrium of a tight contest.
Additionally, it rapidly decomposes when dried on a surface due to the water loss that shifts the equilibrium of the PSOA mixture [7].
When the thermodynamic equilibrium of the system is governed by the reversible association, the destabilization of SWCNTs by neutral salts shifts the equilibrium of the reaction toward the associated state (Fig. 5a).
However, for rich flames, the inert third-body effect increases H-atom production via HCO +M) = H + CO +M) and suppression of the kinetic effect of CO2 by shifting the equilibrium of CO + OH = CO2 + H.
The promoting effect of CO2 is explained either by hydrogen consumption in the reverse water gas shift reaction [Eq. (2)], which shifts the equilibrium of, for example, propane dehydrogenation [Eq. (6)] (two-step path) or its participation in direct oxidation of propane to propylene [Eq. (7)] (single-step path).
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