Sentence examples for shift of specificity from inspiring English sources

Mutation of the leucine residue to either tyrosine or phenylalanine in the context of the class II factor ELF4-DBD resulted in a clear shift of specificity towards class I at −3 position, confirming the importance of this amino acid for the differences in specificity between class I and the other classes.

A shift of epitope specificity was observed with the early response being broad, and the late limited to the HCV-C C-terminus.

The K138R mutant showed a 1.3-fold shift of reaction specificity toward methanolysis compared to the wild type, while the V-95D, I53V, P-96S/F196Y, and Q128H/Q197L mutants showed shifts toward hydrolysis of 1.6 5.9-fold 1.6 5.9-fold

Among other branches, the most likely for having undergone positive selection is not associated with documented shift of rhizobial specificity.

We found signatures of positive selection suggesting episodes of molecular adaptation of NORK in the history of this genus, but with no evidence of correlation with shifts of rhizobial specificity.

Thus, lack of g1 and/or g2 on CXCR4 does not lead to a shift of the coreceptor specificity to allow CCR5-dependent viruses the entry via one of the CXCR4 coreceptor mutants.

From an evolutionary point of view, amino acid changes leading to the shift of enzyme substrate specificity are usually derived from positive Darwinian selection after gene duplication [ 41, 43].

In the current study we used a semi-rational design approach to shift the specificity of subtilisin Carlsberg towards production of peroxycarboxylic acid.

For analytes and IS, retention time windows were constructed based on the previously calculated precision data to implement possible tr shifts in the evaluation of specificity.

Moreover, the observation that OBPs can shift the specificity of Bombyx mori pheromone receptor responses expressed in a human cell line [35] or in the Drosophila "empty neuron" system [36] provided further experimental evidence for the necessity of proper pairing between ORs and OBPs.

In the present study, we demonstrated that chemically modified AddnIκB-PEG-RGD exhibited a shift in specificity of cell entry from its intrinsic CAR-driven entry pathway to an αv integrin-mediated pathway.