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However, these approaches were not developed to detect highly contrasting expression of neighboring genes that undergo a switch-like shift of regulation in a tumor cell.
While the loss of AKI could be compensated for by AKII, the reverse was not true, and a shift of regulation towards the Lys branch took place.
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This observation suggests a shift of translation regulation.
(PDF 714 kb) Additional file 15 Shift of epigenetic regulation between normal and cancerous lung tissues.
Our results suggest that genes targeted by methylation are not only very different between different normal tissues, but more importantly that they are very different between normal and cancerous samples of a given tissue suggesting a shift of epigenetic regulation between normal and cancerous tissues.
The danger for the environment in this approach is that even if the majority of reforms remove unnecessary or obsolete legislation (a cursory glance at a few of the proposed changes confirms this is probably the case) there is room for the government to shift the direction of regulation away from environmental protection.
Another is the need to shift the responsibilities of regulation and governance itself away from, well, government, and towards unelected, unmandated private enterprise since who can better know what business needs to prosper than business itself?
Its assessors found "interns worked both overtime and night shifts, violations of regulations governing internships".
Over the years, the lawsuit has led to a complex and shifting set of regulations governing police investigations that intersect with political or religious activity.
In shifting the focus of regulation from reining in institutional and corporate malfeasance to perpetual electronic guidance of individuals, algorithmic regulation offers us a good-old technocratic utopia of politics without politics.
At later stages of Fe deficiency, IDEF1 shifts its pattern of regulation, with decreased impact on Fe uptake-related genes (Table 1) (Kobayashi et al. [2009]).
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