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Indeed, in case of suboptimal coverage rates, the positive effects of vaccinating children might be offset by a shift of infection to older age-groups who are at risk of more severe disease [ 2, 9].
UVV was only limited to Regions with specific vaccination programmes: in order to avoid a possible shift of infection towards adulthood, only Regions likely to guarantee a level of Vaccination Coverage (VC) over 80%, were recommended to introduce varicella vaccination.
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The authors discuss that these decreased levels of transmission at some areas without proper immunization could result in shifting of infection to older age strata, resulting in more symptomatic and fatal cases [ 17].
The decreased mortality rate obtained with antiretrovirals (ARVs) induced a shift of HIV infection toward a chronic condition and increased the fraction of patients aged >50years.
The collections of these baseline data are critical for monitoring future changes in population exposure rates, shifting demographics of infection, and vector bionomics.
Several have predicted northward shifting zones of infection with modest impacts on overall extent of distribution (Rogers and Randolph, 2000; Hay et al., 2004; Nakazawa et al., 2007).
The number of antifungal agents available continues to increase in the setting of a shift of candidal infections to those caused by non- albicans species.
However, emergence or introduction of a virus that causes disease in wild birds or animals would likely result in a disproportional shift in prevalence of infection in wildlife brought to rehabilitation hospitals, thus making occupational contact more risky.
For example, vaccination may shift the age of infection upwards, which may be associated with increased severity of disease or associations with other diseases may exist (Heininger and Seward, 2006); reflecting additional effects that can be covered within a dynamic approach, next to herd protection.
46 In view of existing infection control guidelines mainly addressing MDR gram-positive organisms (ie, MRSA and VRE), a shift of attention in infection control strategies that focus on the emergence of MDR GNB among RACF residents is warranted.
The upward shifting of age of infection is a common feature of many vaccination programs (11 ).
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