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Most of these alterations can be attributed to cellular changes, including the decline in cell abundance and functionality and a shift of cells with chondrocytic phenotype to a fibrocytic phenotype.
Moreover, the rate of accumulation of flv2 and flv4 transcripts upon shift of cells from high to low CO2 is strongly dependent on light intensity.
For this purpose, transcripts of the four flv genes in Synechocystis WT were monitored by RT-Q-RT-PCR upon a shift of cells from HC to LC, in combination with different fluence rates (10, 50, 600 µmol photons m−2 s−1).
Meanwhile, the prolonged lag phase in adverse condition reflected a physiological shift of cells to adapt environmental stress.
Adding CCCP causes loss of mitochondrial membrane potential (MMP) and should cause a shift of cells out of the top left where alive cells can be found.
Remarkably, the shift of cells from glucose to methanol is associated with a significant increase in mitochondrial volume fractions (figure 5).
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There was no major shift of cell death pathways from apoptosis to necrosis, although a small portion of OHCs showed signs of secondary necrosis.
There has been a shift of cell culture substrates from single purified proteins, to more complex materials that attempt to mimic the complex native ECM [9].
Several lines of evidence indicated that miR-705 and miR-3077-5p worked together to mediate the shift of cell lineage commitment of MSCs to adipocytes during osteoporosis.
However, the gradual loss of DNA and H3K9 methylation and gene silencing observed after day 5 was not correlated with a shift of cell populations.
A shift of cell death pathways is also a reasonable explanation for the failure of only silencing RIP3 to confer a protective effect against NIHL.
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