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Loss of Dab2 expression may thus shift localisation of TGF β receptors to lipid raft compartments leading to increased MAPK signalling and EMT.
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Moreover, the shift in localisation is accompanied by drastic changes in the chromatin with massive nucleosome loss (Kristell et al. 2010).
The gene clusters that are repressed by nitrogen and reside at the nuclear periphery shift in localisation away from the periphery towards the nucleus interior upon induction by nitrogen starvation (Alfredsson-Timmins et al. 2009).
Importantly, using live cell confocal microscopy, we can demonstrate that the increase of the high mannose form of the mutated receptors is paralleled by shift in localisation of these receptors, a phenomenon which is also dependent on the constitutive activity of the mutant proteins.
During the past few decades, a shift in the localisation of the tumours has been observed.
Immunoprecipitation (IP) has been used to determine whether the observed shift in cellular localisation of p53 and MDM2 after cisplatin treatment affects MDM2 p53 complex formation.
This phenotype appears to be crucially dependent on the expression level of the protein, and is associated with a significant shift in FUS localisation to the cytoplasm without concomitant loss of FUS from the nucleus.
Our immunohistochemical analysis showed that although virtually all (96%) IDC samples have lost nuclear MI-ER1 α, only half of the DCIS samples showed this shift in subcellular localisation.
In follicular adenomas, a shift of pendrin localisation from the apical membrane to the cytoplasm was observed suggesting partial retention of protein in intracellular compartments, most likely membrane-associated.
This newly found role for NRP1 correlates with its mobilisation away from mature focal adhesions in VEGF-induced β3-integrin-depleted cells; this shift in cellular localisation does not occur in wild-type cells.
While there was no difference in the number of COX-2-expressing stromal cells after LGG, there was a shift in cell localisation from the villi to the crypt region (figure 6C,D).
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