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The discovery that the transition from metarhodopsin I to metarhodopsin II involves an actual shift of the retinal part of the molecule from linkage to lipid to linkage to protein reinforces the belief that this particular shift is sufficient to lead ultimately to electrical discharges in the optic nerve.
In agreement with this idea, a temperature shift is sufficient to revert the aging phenotype of PHB depletion.
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Because overwintering R. rickettsii-infected ticks are likely exposed to much greater temperature differentials, we repeated the genomic transcriptional profiling after maintaining infected Vero cell cultures for 2 or 24 hrs at 4°C to determine if this greater temperature shift was sufficient to globally alter gene expression.
Given these computationally challenging molecules prompted us to examine whether the sensitivity of DFT-computed chemical shifts is sufficient to discriminate between correct and incorrect structures by using various metrics.
The magnitude of this shift to is sufficient to generate a reduction of 11.5% at most in the GC content in the saltans/willistoni group.
In all cases in which the chemical shift resolution is sufficient, the equilibrium products of oxaloacetate have signal amplitudes larger than those of [C]bicarbonate, indicating that PC flux is larger in the liver than PDH flux.
Although the fitness increase conferred by mutator alleles after an environmental shift is often sufficient to drive fixation in populations, this fitness increase is often relatively small (Sniegowski et al. 2000; Shaver et al. 2002).
We show that a simple point neuron receiving convergent inputs from high-spontaneous rate auditory nerve (AN) fibers, with no special currents and no peri-stimulatory shifts in firing threshold, is sufficient to produce much of the diversity seen experimentally.
It was found that low content of silsesquioxane building blocks is sufficient to shift the mechanical behavior of the matrix from a brittle character to a flexible tough one.
However, in this model, with the assumptions of an integrated market, linear demand, monopoly unions, and absence of transportation costs, an infinitesimal difference in wage rates is sufficient to shift the entire production towards the less expensive plant; thus, a decreasing return to scale technology seems to be a more realistic assumption.
If the energy barrier is low, even a minor perturbation is sufficient to shift the protein conformational ensemble.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com