Exact(2)
Well-characterized tumor suppressor genes such as the retinoblastoma gene RB also had internal rearrangements and it is possible these genes were inactivated through frame shift in the transcript or by removing important protein domains.
The inclusion of exon 11 causes a frame shift in the transcript, generating a slightly shorter isoform because of the introduction of a premature stop codon [short and long forms correspond to N and B isoforms in humans, respectively (Hovanes et al. 2000)].
Similar(58)
These result in reading frame-shifts in the transcript.
Potential frame-shifting in the transcripts were checked with the web tool KnotInFrame [ 62].
Interestingly, distinct shifts in the relative transcript abundances of GH families as a fraction of an overall specific activity were frequently observed (Fig. 2).
WRI1 expression also induced a shift at the transcript level in the organelle distribution of glycolysis with carbon flux being directed to the plastid.
The goal of SSEM-Lasso's training phase was to infer a gene interaction network that filtered out gene-gene regulatory "patterns" so that genes experiencing a true additive shift in their transcript signals emerged above the gene network background.
Whether the shift in PML isoform transcript levels during HSV-1 infection can perpetuate the transformation in PML localization pattern remains to be determined.
The shift in transcript accumulation of genes involved in fatty acid metabolism supports previous observations that the fatty acid composition of sexual tissues of Neurospora differ substantially from the composition of asexual tissues.
Moreover, deletion of the exon 4 results in a shift of the open reading frame in the transcript after joining exons 3 and 5.
The changes upon the 10- and 100-fold light shift in transcript amounts were related to the changes in de novo protein synthesis and plotted in a diagram.
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