By exchanging these two flanking amino acids (Val66Ala, Met163Leu) in hsCK2α1 335, a C-terminally truncated variant of hsCK2α, the cosubstrate specificity shifted in the expected direction so that the mutant strongly favours ATP.
This demonstrates that light acrophase shifted in the expected direction in response to the morning bright light treatment.
For 9 of the 12 comparisons, we find the distribution of genes significantly shifted in the expected direction of overlap, and in the three other comparisons the direction of change was still correct, but did not reach significance.
Insufficient use of OPV in preventive SIAs will lead to the need to shift more of the expected doses in the mOPV stockpiles available for outbreak response to filled doses instead of bulk, and could lead to greater ultimate OPV use if the outbreak response does not prevent the outbreak from spreading widely.
The mark he is happiest to have made on the N.F.L., Dungy said, is a subtle shift in the conduct expected of successful coaches.
Pierre Rollin, one of the agency's senior Ebola experts, said in an interview last week that multiple CDC teams are preparing to deploy if needed, with each shift in the Congo expected to last four to six weeks.
This means that 16 of the 18 populations experienced a shift in allele frequency in the expected direction, qualitatively matching theoretical predictions (one-sided exact binomial test, p <0.001) even though the natural populations are vastly more complicated than our model.
The method we introduce, PARADIGM-SHIFT, detects a difference in the expected activity of a gene in its downstream neighborhood relative to what is expected given its upstream neighborhood.
In order to compare results across these studies, we calculated the degree of compensation as the difference between the error in heading perception and the shift in FOE based on the experimental parameters, normalized by the expected shift in FOE ([FOE shift-heading error]/FOE shift).
A small shift of amino acid usage in the expected direction is observed in endothermic ('warm-blooded') mammals and chicken compared to ectothermic ('cold-blooded') vertebrates with lower body temperatures; this shift is not simply explained by nucleotide usage biases.
