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Earlier assumptions about a shift in target cells favouring X4 over R5 viruses [ 4] are now questioned [ 37].
Such interstitial translocation represents a shift in target site away from the alveolar space to the interstitium, potentially causing direct particle-induced effects there.
Since the precursors in Experiment 1b elicited a significant shift in target categorization, it was predicted that Experiment 3a would result in a strong shift in categorization.
Most of these residues were shown to occur in regions predicted to be involved in PTP substrate specificity suggesting a recent shift in target of these PTPs.
In JURKAT cells overexpressing oncogenic NKLs we observed a shift in target gene activity from HES1 to HEY1, suggesting differences in their mode of interaction with SPEN.
Earlier work by Wodarz et al. [ 17] and Callaway et al. [ 18] allows more realistically for a mixed infection and investigates how the shift in target cells and HIV specific T cells can dynamically induce a shift from R5 to X4 viruses.
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The shift in targeting reflects three developments.
Second, there appears to be shift in targeting, particularly away from so-called "signature strikes" that rely more on behavior than specific intelligence to justify kills.
It is a shift in targets for the terrorist group, which has thus far set its sights on Yemeni military units, rather than staging attacks that hurt the local population, like the marketplace bombings conducted in other Arab countries.
The figures confirm "an enormous shift in targeting toward criminals," said Susan B. Long, co-director of the Transactional Records Access Clearinghouse at Syracuse University, which analyzes federal law enforcement data.
Next Jump CEO Charlie Kim, who recently partnered with LivingSocial to power daily deals across his commerce network, sees a shift in targeting from broadcasting deals to narrowcasting them.
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