Sentence examples for shift in specificity from inspiring English sources

These experiments demonstrate that the blind shuffling can achieve a huge shift in specificity which was a known, highly effective single-site mutation designed using structural knowledge.

Indeed, the F146A mutant was not inactive as previously reported (Baker & Urban, 2012), but it rather showed a shift in specificity for the P4 residue.

The M74A and K86Q mutations each decreased total activity slightly and showed a shift in specificity away from 14 0 and 16:16

The G4 and G5 strains showed a clear preference for A secretors over B and O secretors, which indicated a shift in specificity toward recognition of the A antigen from the H and B antigens, as reported (2 ).

In the present study, we demonstrated that chemically modified AddnIκB-PEG-RGD exhibited a shift in specificity of cell entry from its intrinsic CAR-driven entry pathway to an αv integrin-mediated pathway.

Position 184, which caused a shift in specificity from 14 0 and 16:1 toward 16:0 and 18 1, is located 11 Angstroms from its closest catalytic neighbor and is on a flexible loop that has the potential to shift during binding and/or catalysis.

In the ELM resource, and by association in iELM, however, these subtle shifts in specificity are not necessarily fully explored.

Second, the P450s appear to have experienced shifts in specificity to favor either the fused ring or the phenolic ether substrates.

These domains are abundant in higher eukaryotes with small differences in amino acid composition leading to subtle shifts in specificities (Encinar et al., 2009; Gfeller et al., 2011; Huang et al., 2008).

Most of our designed mutations narrow the gap between the affinity of Raf for RasGTP and RasGDP, producing the desired shift in binding specificity towards RasGDP.

LipC is fundamentally a cold-acting lipase, capable of tolerating high concentrations of ions and heavy metals, and showing a shift in substrate specificity when incubated at higher temperatures.