Critically, these tasks predicted an increase in the hit rate, without an associated increase in false alarms, showing a beneficial shift in sensitivity without a detrimental shift in the criterion.
Both assumptions could therefore suggest a shift in sensitivity between the transient brain responses related to light onsets and the sustained responses associated to task blocks.
Interestingly, it is not a complete insensitivity to auxin as observed for division but a shift in sensitivity suggesting that ABP1 is likely to contribute to this auxin response together with other regulators.
Rather, given the resemblance in diurnal rhythm of ECOD activity and susceptibility to propoxur, and similar dampening of these rhythms under constant light, it is likely that daily variation in cytochrome P450 activity is responsible for the daily shift in sensitivity to propoxur.
Therefore there was an apparent 10-fold shift in sensitivity to poly-APS with a 9°C drop in temperature.
In contrast, the M4 KO mice exhibited robust deficits in the acquisition of both contextual and cue-dependent fear conditioning, effects that were not confounded by a shift in sensitivity to the shock stimulus.
This was demonstrated by the greater than 6-fold shift in sensitivity to compound 5 in the cancer versus the normal cells (IC50 of 1.3 μM for HCC41017 versus 8.1 μM for HBEC30KT cells).
These include the increased presence of CD24/CD44 and CD133 surface markers and ALDH expression in DiI+/SCCs, the morphological and genetic finger print of EMT including increased invasiveness and tumor initiating potential, a shift in the activity of stem cell pathways, and a shift in sensitivity to chemotherapy.
These contextual relationships between species levels and sensitivities as revealed in the series of DyNSIMs provides insights into the predicted shift in sensitivity of AP-1 activity from Fos Jun heterodimer based mechanisms to that of Jun homodimer based reactions over time.
In residues 158 162 (see above), Ile and Asp are both valines in PI5P4Ks α and β and mutating these together in PI5P4Kγ+ caused a small shift in sensitivity to NIH-12848 [inhibition by 10 μM NIH-12848 was 96% ± 1.5 in WT PI5P4Kγ+ and 71% ± 2.6 in the (EH,IV,DV) PI5P4Kγ+ mutant].
