Sentence examples for shift in motif from inspiring English sources
For each case where eh1 motif position is not conserved, the shift in motif position correlates with changes in the size of the coding region C-terminal to the WHD.
For instance, the greater enrichment for SP1 functional categories among human SP1 target promoters containing an ancestral GA box is consistent with a functional shift in motif preferences, rather than a mutation-driven change in sequence content.
Notably, a similar replacement to isoleucine was found at site −13 in birds, representing a one-to-one correspondence between substitutions at this site and shifts in SP1 motif preferences.
The average motif RMSD for PDZ with 6.1±8.0Å was unusually high, possibly because of shifts in the ELM motif position.
Selective use of exons results in a frame shift in translation, generating a WW-containing motif at the C-terminus of FHL1C, which can bind to RBP-J.
More importantly, however, the GAA_AAA_A sequence is in a different frame from the −1 PRF X_XXY_YYZ shift site motif, making it inconsistent with the tandem −1 slippage model.
The predictions for QuEST and HPeak were both consistently shifted downstream from the nearest high confidence motif occurrence (3' direction, positive shift in Figure 7), indicating some unknown, systematic bias in these unrelated algorithms.
This correspondence was unique to site −13; no other amino acid position in any of the three zinc fingers, either alone or in combination, coincided with the shifts observed in SP1 motif preferences in both lineages.
Why the shift in perspective?
The shift in perspective matters.
