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However, the literature reports very few unambiguous connections between changes in amino acid substitution rate (evolutionary shift) and functional shifts, and the role played by the environment is often limited to speculative discussion.
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Evolving performance expectations and demand create uncertainty regarding the ability of long-life pavements to reach environmental goals because time-dependent factors, such as technology shifts and functional obsolescence, affect their ability to serve for their entire design life.
Batch WAS fermentation tests were carried out to determine the acid-producing ability of acclimated bacteria in different conditioning systems in the absence of carbohydrate substrates, and high-throughput sequencing analysis was conducted to probe the microbial community structure shifts and functional community evolutions induced by different ARs conditioning.
These results were in full agreement with our initial analysis and thus established a correlation between evolutionary shift and the functional diversification, i.e. the lipase and feruloyl esterase A activities.
FNA NK cells demonstrated a highly significant shift in phenotype and functional markers (figure 2).
Hydrothermal systems are famous for their remarkable physico-chemical and concomitant biological variations: orders of magnitude changes in pH and elemental concentrations, steep temperature gradients, and dynamic temporal shifts support taxonomic and functional biodiversity that is unparalleled in most other environments on the planet (Barns et al. 1994; Shock et al. 2010).
An increased susceptibility to pathogens and bacterial community shifts (abundance change and functional change) were observed by administration of antibiotics in a rodent model of intestinal inflammation.
Comparative metagenomics of permafrost was recently applied to both the frozen and thawed states to analyze the shifts in microbial and functional composition [ 78].
Manual and instrumental laxity (Lachman test, Pivot-shift test, Rolimeter) and functional outcome scores (International Knee Documentation Committee sore, Tegner activity level) were measured after one year follow up.
The metabolic cost and functional shift hypotheses regard the architecture underlying immune functionality fundamentally different.
Chapter 5 begins by discussing artificial selection, offering the chance to introduce the concepts of pleiotropy and functional shift and to sharpen the idea of adaptation.
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