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As a result, we often found a PC molecule between two sterol molecules; the big polar head of a PC can effectively shield cholesterol from water.
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Besides this effect, mitochondrial cholesterol loading shields mitochondrial membrane, impairing BAK/BAX oligomerization in MOM and subsequent MOMP formation and represents an additional mechanism of cell death resistance in tumor cells.
Designated a hydrophobic handoff, this transfer occurs in such a way that hydrophobic cholesterol is shielded from the aqueous environment (Kwon et al., 2009).
Above this concentration threshold, cholesterol is less shielded by the membrane lipids and becomes increasingly available for PFO binding.
Based on these two chemistries, we selected a variety of hydrophobic moieties, including fatty acids, vitamin E, Boc-protected amino acids, artesunate, cholesterol, and deoxycholic acid, to shield the 10-hydroxy group of SN-38.
Cholesterol fine.
The cholesterol.
REMEMBER cholesterol?
No cholesterol".
Another shield.
"I have cholesterol issues.
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