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It has a thin rubbery body, a skeleton of gold, and an unusual power source: a sheet of heart cells that contract when illuminated with pulses of blue light.
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A lab at the Hannover Medical School in Germany is one of several experimenting with 3-D printing of skin cells; another German lab has printed sheets of heart cells that might some day be used as patches to help repair damage from heart attacks.
The intervention was a fact sheet on heart murmurs in children (Additional file 1), which was sent to the last one third of the parents (n = 70).
Currently, additional approaches are being explored, including transplantation of new cell types (e.g., human ESC-cardiac progenitor cells (Menasche et al, 2015) or iPSC-CMs), or application of alternative delivery approaches such as implantation of in vitro constructed cell sheets of engineered heart muscles (EHMs) (Fig 2; Zimmermann, 2013; Emmert et al, 2014; Hirt et al, 2014b).
"When I saw this sheet of paper, my heart sank.
The present study investigated whether the HGF sheet could prevent the progression of heart failure in stroke-prone spontaneously hypertensive rats.
The fact sheet presented the most common causes of heart murmurs in children and emphasised the low risk of having a serious heart condition with an isolated heart murmur (Additional file 1).
Y. Sawa and S. Miyagawa introduced the experience of their cell sheet-based heart regeneration because their group is the top leader of heart regenerative therapy based on sheet technology.
I feel this," he holds up the sheet of numbers again, "in my heart".
The purpose of this study was to assess anxiety and concerns in parents of children referred for evaluation of a heart murmur and to evaluate the effect of receiving a fact sheet about heart murmurs before the cardiologic consultation.
The result was a "medusoid"—a simple artificial creature composed of heart muscle cells overlaid on a sheet of silicone molded into a shallow cup rimmed with flaps.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com