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Epithelial sheet movement: protein and glycoprotein synthesis.
Murrell, M., Kamm, R. & Matsudaira, P. Substrate viscosity enhances correlation in epithelial sheet movement.
Epithelial sheet movement: effects of tunicamycin on migration and glycoprotein synthesis.
Dorsal closure is a model cell sheet movement that occurs midway through Drosophila embryogenesis.
Dorsal closure proceeds even if we ablate one (but NOT both!)of the tissues responsible for closure, indicating that this model cell (epithelial) sheet movement depends on redundant forces that in concert drive morphogenesis.
These cells are referred to as a "metastable phenotype" and distinguished from both epithelial and mesenchymal cells by characteristics such as residual E-cadherin, nuclear β-catenin and sheet movement [ 13, 26].
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The nonmuscle myosin II heavy chain (MHC encoded by zipper is required for cell sheet movements in Drosophila embryos.
Dorsal closure is a key process during Drosophila morphogenesis that models cell sheet movements in chordates, including neural tube closure, palate formation, and wound healing.
Dorsal closure is characterized by complex cell sheet movements, driven by multiple tissue specific forces, which are coordinated in space, synchronized in time, and resilient to UV-laser perturbations.
By observing the Drosophila epidermis during embryonic development using confocal time-lapse microscopy, we have investigated how signaling through the Jun-N-terminal kinase (JNK) pathway governs the tissue sheet movements that result in dorsal closure (DC).
Farooqui, R. & Fenteany, G. Multiple rows of cells behind an epithelial wound edge extend cryptic lamellipodia to collectively drive cell-sheet movement.
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