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Tppp3 is a specific marker for tendon sheath differentiation [ 20].
Histopathologically, most of these tumors are completely or partially composed of spindle cells and display smooth muscle or nerve sheath differentiation.
Malignant peripheral nerve sheath tumor (MPNST) is an uncommon malignancy defined as malignant tumor arising from a peripheral nerve or showing nerve sheath differentiation, and accounts for about 5% of all soft tissue sarcomas [ 1, 2].
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Interestingly, in newborn mice carrying an epidermal-specific Dicer deletion, HFs were stunted and hypoproliferative, hair-shaft and inner-root-sheath differentiation was initiated, but the mutant HFs were misoriented, suggesting that processing of miRNAs and their assembly into the RNA-induced silencing complex is necessary for hair-follicle biology.
Based on these histological and immunohistochemical features, a diagnosis of malignant peripheral nerve sheath tumor with heterologous rhabdomyoblastic differentiation was made.
In this manuscript, Wang et al. address the role of somatic inner germarial sheath cells (ISCs) in promoting differentiation of germline cells displaced from the stem cell niche.
To delineate the role of Eph-ephrin signaling during the final stage of oligodendrocytes differentiation when myelin sheath formation is initiated, forward and reverse signaling must be analyzed separately.
The capacity to heal wounds relies on the rapid proliferation and migration of epithelial cells located at the wound margin and their ability, once the wound bed has been completely covered by an epidermal sheath, to reset the terminal differentiation program, restoring a complete stratified epithelium.
We uncover the origin of all three glial sheaths and describe the larval differentiation of each peripheral glial cell in detail.
The host's reaction to the pathogen involves trans-differentiation of bundle sheath cells into functional xylem elements under the control of the vascular-related NAC domain 7 transcription factor [ 29].
Although previous studies with rodent cells demonstrated that hair follicle sheath and papilla cells possess multi-lineage differentiation potential, human hair follicle derived mesenchymal stem cells (hHF-MSCs) have not been characterized in detail in terms of their multipotency.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com