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Such a shattering phenomenon can be captured and quantified by a mathematical model based on droplet analysis.
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The chromothripsis phenomenon is the shattering of two or more chromosomes and their reassembly into derivative chromosomes in a single catastrophic event [ 28].
This phenomenon, also termed 'chromothripsis' (shattering and regluing of chromosomes), is primarily localized to single chromosomes, but includes multiple structural genomic changes, such as gains, losses and inversions.
The recent discovery of chromothripsis (thripsis means "pulverization" or "shattering into pieces" in Greek), the phenomenon of a single chromosome pieced together from tens to hundreds of rearranged fragments, gives insight into how chromosomal instability can trigger carcinogenesis over a brief mutational time span.
Here, we describe multiple cancer samples in which tens to hundreds of genomic rearrangements have been acquired in a single catastrophic event, a phenomenon we have termed chromothripsis (Greek, chromos for chromosome; thripsis, shattering into pieces).
Arabidopsis has proved to be a useful model to study the phenomenon, where a transcriptional regulator, FRUITFUL (FUL), mediates pod dehiscence by inhibiting expression of genes controlling shattering.
Shattering glass.
Then glass started shattering".
"It was shattering.
A shattering novel.
That barrier is shattering.
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