Exact(9)
There were only very modest radiological deteriorations in these two treatment groups of 1.0 Sharp units and 1.6 Sharp units, respectively (the Sharp scale measures bony erosion and joint space narrowing, and the scale ranges from 0 to 398).
At year 2, patients receiving combination therapy continued to have significantly less radiographic progression (mean change 1.9 Sharp units) compared with those treated with either adalimumab (5.5 units) or MTX (10.4 units) monotherapy (P <0.001 for both comparisons).
After 2 years of treatment, patients receiving combination therapy continued to have significantly less radiographic progression (mean change, 1.9 Sharp units) compared with those receiving either adalimumab monotherapy (5.5 units) or MTX monotherapy (10.4 units) (P <0.001 for both comparisons).
Figure 2 shows estimated marginal means of the fitted model (mean HAQ scores adjusted for age, sex, DAS, treatment and time) for each category of 10 Sharp units and clearly points to an increasing trend.
To visualise the adjusted relationship between the HAQ score and the Sharp score, Sharp scores were divided into six categories of 10 Sharp units each and estimated marginal means were calculated.
The rationale for this particular cutoff was that the progression of radiographic joint damage by 20 Sharp units corresponds to an irreversible deterioration in physical function as defined by the HAQ disability index of 0.2, approximately the minimum clinically important difference for this outcome [ 26].
Similar(49)
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If reader 1 factors in a unidirectional trend he may score two other joints positively, with consequences for his total Sharp score (+3 units) and for the grand mean score (+1.5 units), whereas reader 2 would have no reason to do that.
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