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Seronegative vs seropositive analysis: Symptom duration, P = 0.85; DAS28-CRP, P = 0.72; CRP, P = 0.56; Sharp score erosions, P = 0.28; Sharp score narrowing, P = 0.09.
XR total Sharp score, XR erosion score and XR joint-space narrowing (JSN) score all increased at 24 weeks, but only XR total Sharp score increased significantly.
The most provoking limitation, though was the small signal observed with the Genant-modified Sharp score.
A high ESR at baseline also predicted an elevated final total Sharp score in our study.
We used the MCID as determined by the OMERACT for the modified Sharp score.
The Sharp Score revealed no significant change during the study period.
The severity of joint space narrowing was also quantified by the Sharp Score.
At baseline, 19 patients (20%) had significant structural damage (total Sharp score higher than 5.5).
Radiographic joint damage was assessed according to the van der Heijde modification of the Sharp score.
The total Sharp score is derived from the combination of erosion and joint-space narrowing scores.
Joint damage was assessed by the total modified Sharp score (0 390 points).
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