The Hancock and Sharp method of comparing the kinetics of isothermal solid-state reactions was applied.
Conclusions: This study demonstrates that, and shows how, the investigated factors influence the variability of the modified Sharp method.
The results from Hancock and Sharp method suggest that the phase boundary control is likely to be dominant.
This study focuses on the influence of the following 4 factors on radiographic scores according to van der Heijde's modification of the Sharp method: intraobserver variation, interobserver variation, follow-up time, and number of measurement occasions within a patient series.
The observers used the Sharp method as modified by van der Heijde [ 13].
Digitised images were scored by two readers, using the van der Heijde-modified Sharp method.
Films were scored by the van der Heijde-modified Sharp method [ 2].
MRI-JSN scores were compared with XR-JSN scores for the 13 joints included in the Genant-modified Sharp method.
One radiologist scored all XR images using the van der Heijde-modified Sharp method blinded to visit order.
Radiographs were scored chronologically by two independent rheumatologists (OM and PF) according to the van der Heijde/modified Sharp method [ 21].
Radiographs of hands and feet (read according to the modified Sharp method) and the Health Assessment Questionnaire were used to quantify structural and functional severity.
