Constitutive concentrations of S1P in most tissues are very low, but high nanomolar concentrations can be found in blood and lymph, creating a sharp circulation-tissue S1P gradient responsible for trafficking of immune cells from secondary lymphoid tissues to blood vessels (21).
Since its former parent company, Times Mirror, was bought by Tribune in 2000, the paper has registered sharp losses in circulation, deep staff cuts and a scandal over falsified circulation figures.
After the victories of the civil rights movement in the 1960's, many older black newspapers suffered sharp declines in circulation.
In more serious fare, the North American edition of The Economist had a sharp increase in circulation, to 694,000 from 601,000.
That mix has important implications for other media, particularly newspapers, which have been contending with sharp declines in circulation and advertising.
When Village Voice owner Leonard Stern bought LA Weekly in 1994, the Voice was in the throes of a sharp decline in paid circulation.
The contrast between the strong heating of the continent in the summer months May too September) and the chilling in winter produces sharp seasonal variations in atmospheric circulation and also enhances the role of local centres of atmospheric activity.
In agreement with previous reports [35], [36], after vaccination with '05-TIV, effector B-cells transiently appeared in the circulation with a sharp peak around day 7, and quickly disappeared thereafter (Figure 3 and [5]).
In these subjects, the effector IgA and IgG antibody secreting cell (ASC) responses appeared in the circulation with a sharp peak around day 7, and quickly disappeared thereafter (on day 30) [ 40].
Jorge Tedesca, the deputy minister of the economy, said on Sunday that "emissions by the Central Bank" were responsible for what he called a sharp "increase in the money in circulation".
