Using population surveillance methods [28], [29], [30] we confirm a sharp rise in adverse cardiovascular events within eight months of the market introduction of rofecoxib and one year after launching of celecoxib.
Second, explicit policies to diminish the currency mismatch of the government's finances lessened their vulnerability to sharp depreciation episodes and adverse external shocks.
Reviewing the broad parameters of the programme this paper argues that, while a sharp fiscal adjustment was necessary, adverse distributional consequences were partly mitigated by government.
Lawsuits frequently engender in defeated litigants sharp resentments and hostilities against adverse witnesses, and it is argued, not without persuasiveness, that rules of law must be so fashioned as to protect honest witnesses from hasty and spiteful retaliation in the form of unfounded perjury prosecutions.
Lord Mandelson, the Blairite former Cabinet minister, said : "If Labour wants to fight the next election with the pledge of more capital spending, the party will need to keep a sharp eye open for any adverse market reaction as the continuing high level of debt as proportion of GDP could weaken confidence.
In fact, associated risks are huge: 1) the trader posting limit orders may accumulate imbalanced inventory, resulting in sharp market losses due to adverse price movements; and 2) the trader always risks ending up on the losing end of the trade, facing a trader better-informed about the market's imminent direction.
The adverse effects from a sharp increase in the minimum wage may not be as severe as some opponents fear, however.
"In particular the possibility that the potential vulnerabilities stemming from higher debt levels do in fact crystallise at some point and trigger a sharp demand slowdown that could have an adverse impact on monetary stability".
BACKGROUND: Evidence that long-term hormone therapy (HT) may increase the risk of serious adverse events led to a sharp reduction in all HT use, including short-term use for vasomotor symptom relief.
But such a policy would mean that the adverse shock is reflected in a sharp fall in output.
