Sentence examples for sharing of compounds from inspiring English sources

The approach was implemented by assigning reactions and metabolites to a network representing each guild (suffixes on metabolite identifiers prevented sharing of compounds common to the metabolism of multiple guilds), while explicit transport reactions accounted for the exchange of metabolites between guild members and the extracellular space.

Early sharing of lead compounds with academia may help the industry to prioritize between different therapeutic concepts, explore new disease links including patient selection strategies, inform effective combinatorial approaches, and gain insights into potential resistance mechanisms—highly valuable information that would fuel further translational research.

The benefit of sharing of metabolites such as nitrogenous compounds could also initiate granule formation.

We observe that many relationships between different phe-notypic assays are established based on the shared cytotoxicity of compounds in cell- or whole organism-based assays.

The first function, common to all cell lines, learns the shared patterns of compound activity against all cell lines (e.g. substructures enriched for compound activity).

Besides the sharing of photoprotective compounds, these three groups (cyanobacteria, actinobacteria, and Deinococcus) also share a high resistance to dehydration [ 81- 84], which further suggests that their common ancestor was adapted to land environments.

We hence assessed the number of shared active compounds between each pair of kinases as a measure for SAR similarity and compared this number to the distance based on the bioactivity profiles (shown in Additional file 7: Figure S7).

We tested and confirmed this hypothesis by the systematic analysis of the biological activities measured in pairs of assays sharing non-promiscuous compounds in this repository.

The number of shared active compounds was normalized by the total number of active compounds in the variable kinase.

When the number of shared active compounds was normalized by the total number of compounds active, against both the common kinase and the variable kinase (i.e. the other kinase in the comparison), the expected negative relationship was already observed in 46% of all kinases (103 out of 224).

These results suggest that SAR similarity between kinases decreases with higher distance of bioactivity profiles, with changes in the percentage of shared active compounds being the highest for bioactivity profile distances smaller than 0.5.