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A housing shares index was up 0.5 percent.
The 10 giants make up about 50percentnt of the FTSE 100 and 40 per cent of the All Shares index.
Hopes of a fresh round of fiscal stimulus measures today helped London's battered shares index dodge its longest losing streak for eight years.
24,992,502 shares Index is a legend in technology venture capital, having backed Facebook and Skype, as well as British successes such as the clothing retailer Asos and the Moshi Monsters maker Mind Candy.
Photograph: Thomson Reuters Brenda Kelly, chief market strategist at IG, flags up that Astra's rejection has sent the bluechip shares index sliding: In mid-morning trading the FTSE 100 is firmly in the red, down 40 points, hit by the latest twist in the AstraZeneca/Pfizer saga.
Yield spreads between Greek and German ten-year government bonds (the European benchmark) widened to 252 basis points on Wednesday, while the Athens Composite Shares index fell by 2.4% in afternoon trading, with Greek banks some of the biggest decliners.
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From September to November, the all-shares index soared from around 1,000 to nearly 3,700.
In France, the main share index lost more than 8%.
The Shanghai B-share index fell 6.6percentto to 119.02, and Shenzhen's B-share index fell 3.2percentto to 196.63.
The FTSE 100-share index in London was down 0.30 percent.
The Shanghai A share index declined 0.89percentthethe Shenzhen A share index fell 0.45percentt and the Hang Seng Index in Hong Kong plunged 1.7percentt.
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