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These non-thyroidal tissues, that are exposed at a much lower absorbed dose level compared with thyroid, shared regulation of 19/27 and 6/27 recurring genes after 211At and 131I exposure, respectively.
Comparative analysis with other RTK tyrosine phosphoproteomic datasets revealed multiple overlapping pTyr substrates in CSF-1R-, EGFR- and ERBB2-expressing cells and highlighted the shared regulation of caveolin, p120 and PI3-K by these RTK pathways.
In summary, the related phenotypes of PJS, CD, and TS are joined by shared regulation of the mTOR signalling cascade.
Raw expression scores of HDAC1, HDAC2 and HDAC3 correlated significantly with each other (Table 1), suggesting a shared regulation of these isoforms.
Consistent with the shared regulation of STAT3 phosphorylation by leptin and IL6, Pomc and Agrp expression in our study was nearly normal in h IL6tg mice on a HFD.
Finally, we note that our qualitative classification of up-regulated genes in classes 2 and 3 is not mutually exclusive, and the existence of four genes (WD0438, WD1288, WD1289, and WD1290) with sex-biased expression that also show differential expression at larval or pupal stages suggests possible shared regulation of these classes.
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Finally, the analysis of the modularity of TF pairs in the regulatory network revealed a consistent lack of a shared regulation for CTFPs, which might result in a role as integrators of varied inputs.
Shared regulation and function of genes can also be established using coexpression analysis [ 31].
Based on our studies with these four genes, it appears that despite an overarching shared regulation, the finer workings of the mechanism of activation remain varied.
In contrast, the experienced teachers insisted that students comment on each other's ideas and take ownership of the conversation, creating a discourse community of shared regulation [ 91, 98].
Figure 2 reveals that surprisingly few genes shared regulation between the sources of carbon when phk was over-expressed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com