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The first exploration of the data trying to find shared regulated genes, showed a strikingly low degree of overlap between the lists of most significantly regulated genes, when determined by applying an absolute fold change cut-off of 1.2 and setting a false discovery rate at 5% with significance analysis of microarrays (SAM).
List of GlobalAncova derived differentially expressed KEGG functions upon EGF treatment indicating the total number of genes, the number of regulated genes and the number of connections (shared regulated genes) to other pathways.
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In a post line-sharing regulated world, the very same data line can be used for making voice calls as well.
One solution would be to create shared and regulated databases that are in possession of no single entity, thus preventing any party from unilaterally manipulating the data to their own favor.
The fact that thyroid gland and lung tend to cluster together may result from shared positively regulated genes involved in amino acid metabolisms and cell adhesion (see Figure 2).
4) In vitro, LDL cholesterol alone did not significantly induce CX3CL1 or GM-CSF, but had minor effects on VEGF-A expression; CX3CL1 and GM-CSF were coordinately induced by TNFα in endothelial cells, likely due to a shared mechanism regulating their expression.
This research isolated GA-sensitive (qSD1-2/qPH1) and GA-insensitive (qSD7-2/qPH7) natural mutants and provided a set of isogenic materials to test a model for shared mechanisms regulating both seed dormancy and plant height.
Results of KEGG pathway analysis found SWT and estradiol shared certain commonly regulated pathways of "cell cycle regulation", "p53 signaling" and "molecular mechanisms of cancer", further supporting SWT's phytoestrogenic effects.
These are independently expressed intracellularly, and represent broadly shared and commonly regulated systems.
We also looked for the presence of nucleotide motifs that are shared by genes regulated by CRE1, as described in the Methods section.
Moreover the three networks can be merged into a single network underlying the shared biological functions regulated by these eQTLs/genes (Network 8.4 in Additional file 8).
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