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Ligase IV syndrome is a rare differential diagnosis for Nijmegen breakage syndrome owing to a shared predisposition to lympho-reticular malignancies, significant microcephaly, and radiation hypersensitivity.
A possible shared predisposition between ADHD and smoking provides more information about the underlying mechanisms, for example, the involvement of cholinergic and dopaminergic systems and gene gene interactions, which can lead to new therapies for ADHD.
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We report whether the etiology underlying associations of childhood ADHD with adolescent alcohol and marijuana involvement is consistent with causal relationships or shared predispositions, and whether it differs by gender.
They were viewed as "shared genetic predisposition" between the two members of the twin pair.
While some believe it reflects shared biological predisposition (e.g., brain neurotransmitter dysfunctions would predispose to migraine and these manifestations), others believed that shared environmental exposure could explain it [32].
However, evidence suggests a shared genetic predisposition.
In sum, there seems to be a shared genetic predisposition for smoking and ADHD.
Familial clustering of autoimmune disorders has been long recognized and supports a role for shared genetic predisposition.
Medications used to treat autoimmune conditions, shared genetic predisposition and/or direct infiltration of bone marrow by autoimmune conditions, could explain these excess risks of myeloid malignancies.
If rates of both CRC and non-colonic malignancies are high in the Acadian region, it may suggest a shared environmental predisposition for the development of malignancy.
In general, studies of twins are considered the 'gold standard' for determining whether a disease is due to shared genetic predisposition or to shared environmental factors, whereby a higher concordance rate for a disease is expected in monozygotic than in dizygotic twins.
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