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Moreover, a shared pattern between two interacting protein pairs may indicate that both pairs interact through the same shared modular domains.
In our test, removing autocorrelation from CD in male births before testing the relation of employment decline also minimizes the risk of confounding that could arise from a shared pattern between employment and high or low values of CD in males.
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The δ parameter is a measure of the strength of the association between the shared pattern for all 6 conditions and the specific pattern for each condition.
Log2-fold-changes between ChIP and input samples as well as the statistical significance were then evaluated using a generalized linear model (GLM) fit to a negative binomial distribution (see Methods).The repetitive elements that displayed the most shared pattern of Pol II binding between the cell lines were the snRNAs.
Ward hierarchical clustering was used to group all the sex-biased genes based on shared patterns of expression between all six treatments.
For each of our Interpro, OMIM, Mammalian Phenotype Ontology, and phylogenetic tree datasets, shared patterns of annotation between pairs of genes were scored using a method that is functionally similar to the PhenoBlast score used previously for measuring similarity between pairs of Caenorhabditis elegans strains (Gunsalus et al. 2004).
However, the males' sharing pattern differed between when the female's desire matched and when it was conflicting (n = 9, Z = 2.34, p = 0.008; figure 2 a(i) versus figure 2 b(i)).
Species exhibited both shared and unique patterns of phenotypic divergence between the two types of habitats, with shared patterns representing the stronger effect.
It is well established that shared patterns of allele composition can be used to infer genomic relationships between individuals.
Doubleton sharing patterns within and between subpopulations showed the same trend (Extended Data Fig. 2f).
Ioanita-Laza et al. (2011) have proposed a method that compares the sharing patterns of rare alleles between cases and controls.
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