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The results showed that PMM performed the best especially in the case of shared hits.
Many of the strongest shared hits were related to SRC, MTOR, or CDK related pathways.
Furthermore, the biological roles of predicted molecular targets of the shared hits reinforced the biological associations between assay pairs.
The relationships between the biological processes of phenotypic assays are furthermore supported by the role of protein targets predicted for the shared hits.
The third case is probably the most realistic scenario containing both unique and shared hits to a varying degree (see Methods).
Subsequently, to understand the molecular mechanism linking pairs of phenotypic assays sharing chemical hits, we annotated the molecular targets of the shared hits.
Similar(46)
From other parts of the menu came lovely fresh asparagus to roast, and firm garlic noodles were a shared hit.
That is, phenotypic assays share hits with other phenotypic assays and cell-free assays tend to share hits with other assays of the same type.
In any downturn, Ford Motor and Chrysler might take the biggest market-share hits.
Related: Bike Sharing Hits Speed Bump as Soaring Costs Force Some Cities to Shutter Programs.
Based on this assumption, we tested if the removal of promiscuous compounds increases the biological relatedness for assays sharing hits.
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