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Reciprocal responsibility means shared gain and shared pain.
"The concept of shared pain leading to shared gain will help everyone".
To explore the question of possible ancestral relationships among components, we manually examined the most pronounced regions of shared gain across components.
The left half of the image shows Components 3, 5 and 1, revealing a region of shared gain across all three components at 9p21 (labeled B).
Apart from the shared GAIN domain, PKD proteins are unrelated to cell-adhesion GPCRs but also undergo autoproteolysis (Ponting et al, 1999), indicating that the GAIN domain has been utilized by at least two different membrane protein families during evolution.
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TC: Share gain is important.
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