In particular, we introduced the concept of "domain clubs", which are sets of proteins that share common domain compositions.
Paraspeckles are one of the most recently identified nuclear bodies and contain a family of RNA-binding proteins called the DBHS (Drosophila behavior and human splicing) family proteins, which share common domain structures consisting of three RNA recognition motifs arranged in tandem (Fox et al., 2002; Bond and Fox, 2009).
Proteins belonging to different families, but sharing common domains, may thus have escaped detection.
Specifically, the proportion of negative drug pairs that shared common PFAM domains was investigated according to the DRS. Note that negative drug pairs are those without any common targets.
Minicollagens share common domain architectures with a central collagen sequence flanked by polyproline stretches and short N- and C-terminal CRDs.
11 These members all share common domain structures, including N-terminal HEAT Huntingtin, elongation factor 3, protein phosphatase 2A, and yeast kinase TOR 2 (HEAT) repeats, a FRAP, ATM, TRRAP (FAT) domain, a protein kinase domain, and a C-terminal FAT-C domain.
Protein kinases share common catalytic domain structures composed of a small N-terminal lobe and a large C-terminal lobe.
It is hypothesized that cancer proteins, also known as tumor associated genes, may share common functional domains [ 13], and thus a weighted domain score for each tumor associated gene's domain is determined.
Even if only the distinct domains are used, the subsets are still not conditionally independent because they share common pairwise domains.
ERp57 is essential for efficient folding of glycoproteins sharing common structural domains, for instance Type 1 transmembrane proteins, such as α-sarcoglycan, and proteins that possess EGF-like domains, such as β-, γ- and δ-sarcoglycan (Ref. 127).
