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The pairing of the chemokines to their receptors has been carried out, mainly by receptor binding assays, and has identified receptors that are specific (bind to a single ligand) or shared (bind more than one ligand).
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Conservation numbers reported in the manuscript are based on the PECAN alignments; we note that absolute EPO numbers are slightly higher (e.g., 6,946 five-way shared bound regions in human out of a total of 50,482 human CTCF-bound regions included in the EPO alignment), as a higher fraction of the respective genomes are contained in the MSA.
We report the fraction of human-unique respectively five-way shared CTCF bound regions in liver overlapping ubiquitous binding events.
Shared anxiety binds Rick, Philip, and Denise closer together.
A shared history binds the boomers — as do, broadly speaking, some shared traits.
It has been battered by bombings around its edges, but the war has been kept from its heart, largely because of its ancient, shared past, bound by trust and generations of intermarriage.
Annotation Analysis We submitted the human coordinates of the five-way shared CTCF bound regions to GREAT version 1.8 (McLean et al., 2010 ) using default parameters (Basal+extension: 5000 bp upstream, 1000 bp downstream, 1,000,000 bp max extension) and included significant associations for "GO Terms Biological Process," as well as "MGI Phenotypes" in Table S2.
The sequestering function of scaffolds is implemented by expanding the system to include two different states of the "shared" component: bound to the scaffold (denoted x 1 N, for aNchored to the scaffold), and free in the cytosol (denoted x 1 C ).
The crossroads location brings new attention to the shared interests that bind town and gown.
The show's British sponsor suspended its support, but the incident was an unhelpful warm-up for a chancellor stressing the cultural ties and shared values that bind the two countries together.
For all the camaraderie and shared experiences that bind those who play professional golf at the highest level, the royal and ancient game can be a bitchy place, as Ian Poulter will no doubt testify after his experience at the hands of the locker room wags earlier this year.
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