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At present, most government websites have not given full play to the internet's characteristic such as share, interaction.
Hence, in the PIN, a topological overlap (or modularity) O ij = 1 implies that TFs i and j interact with the same proteins, while O ij = 0 indicates that i and j do not share interaction partners.
In agreement with that study, we find that paralogous proteins are more likely to share interaction partners than one expects by pure chance alone (see the caption to the Fig. 3).
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The capacity to share interactions is one determinant of the ability to sustain a digital community, thus creating a sense of belonging (Burnett, 2000; Teo et al., 2003).
Three of the five anthranilate phosphoribosyltransferase paralogs (LOC_Os06g41090, LOC_Os04g39680, LOC_Os05g30750) did not share interactions with other tryptophan biosynthetic enzymes and clustered separately (lower left corner of Figure).
As we have learned from our work, diseases share interactions through molecular networks.
All the proteins v ∈ V \ { u} that share interactions with u are sorted according to the weights w({ u, v}) in decreasing order.
Based on the protein pool and PPI information, a rough PPI network can be easily constructed by linking proteins that share interactions.
Thus, Tor1 and Pka1 share interactions to the transcription factors Gat1, Gln3 and Gzf3 that are involved in nitrogen metabolism and could have been mediators of the transcriptional changes in the studied conditions.
Tor1, Pka1 and Snf1 share interactions to the transcription factors Gln3 and Gzf3 that thus can be considered as probable active transcriptional regulators at low specific growth rate conditions.
Analysis of the crystal structures reveals few shared interaction types, highlighting proton-arene and key CH O hydrogen bonding interactions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com