Although Francisella novicida (also referred to F. tularensis subsp. novicida [3]) is avirulent in humans, it behaves similarly to F. tularensis in human and mouse macrophages [4], shares biochemical features with F. tularensis [3], [5] and exhibits an LD50 in mice similar to F. tularensis via the pulmonary route [2], [6].
Tregs share several biochemical features with anergic cells [32].
The pathways involving small RNAs in plants share common biochemical features.
Given that all CDCs share similar biochemical features and have a similar overall structure [ 2], the purification method described here should be applicable for other CDCs.
These rescuing alleles and the oxidized BiP share important biochemical features in vitro in that they are defective in ATP hydrolysis, are unable to cover the kar2Δ but retain constitutive substrate binding activity and serve as better holdases (i.e. hold unfolded proteins better) than the wildtype yeast BiP.
Examination of post-translational modifications of Dpl and PrPC have shown that the two proteins share several biochemical features: both have two N-linked oligosaccharide groups, are anchored to the external cell surface by a GPI (glycophosphatidylinositol) moiety and form intramolecular disulfide bonds [ 4, 9– 11].
In France, every index case animal from infected small ruminant flocks that has been reported since the surveillance began in 1990 has been biochemically tested to distinguish natural scrapie isolates from isolates sharing common biochemical features with experimental ovine BSE (validated by the TSEs Community Reference Laboratory of Weybridge, UK [unpub. data]).
Ataxia with oculomotor apraxia type 1, another recessive ataxia, shares the biochemical features of susceptibility to DNA damage with AT (for a review, see Rass et al., 2007), but also has no clear increased risk of neoplasia (Le Ber et al., 2003).
Many neurodegenerative diseases, also termed as protein conformational diseases [ 1], are characterised by accumulations of misfolded proteins that often share morphological and biochemical features and can colocalise with several other proteins, including various chaperone proteins.
