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Second, we identified all MCEs in the intersection of human-mouse-rat whole genomes that share a sequence of length k≥20 with one of the 321 human miRNA precursor predictions in miRBase.
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We began by interrogating the catalytic profile of Ms0025 and Mag6390, which share a sequence identity of 80% (Table S1 of the Supporting Information), by physically screening a focused library of phosphorylated and unphosphorylated lactones.
All variants of HPV-6 and HPV-11 share a sequence homology of 34 bases upstream of this region (Fig. 3).
As we have demonstrated in this report, certain variants of HPV-16 and HPV-31 share a sequence homology of at least 34 bases downstream of the GP5+ site (Fig. 2).
The kinases of TRPM6 and TRPM7 share a sequence homology of nearly 75%.
In yeast, the hsp70 gene family comprises of fourteen genes, whose protein products share a sequence similarity of approximately 50-96%.
The host Furin is a homolog of the bacterial subtilisin, and these serine proteases share a sequence identity of 23% ∼40%% similarity).
As shown in the protein sequence alignment (Simossis and Heringa [2005]), Tcur1278 and Tcur0390 share a sequence identity of about 82% and both enzymes show a sequence identity of about 61% with TfCut2 (Additional file 1: Figure S1).
Although these two proteins originate from different species and share a sequence identity of only 87%, a pronounced adaptation to their common ligand IDD384 could be registered.
The two Ciona Gβ members share a sequence identity of about 41% between them and are more divergent than that in human.
The crystal structure of human PRPPase and the modelled MtbPRPPase structure can be superimposed with a r.m.s.d. of 0.5 Å based on 303 Ca pairs (the two enzymes share a sequence identity of 44%).
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