Pathways which shared a common profile among the two samples included up-regulated alternative glucose metabolism related pathways (activation of penthose-phosphate pathway, galactose metabolism and degradation, lactose metabolism) and down-regulated glucose metabolism pathways such as transcriptional activation of glucose metabolism genes.
Our gene expression data demonstrated an equal percentage of genes to be specifically regulated during adipocyte and osteoblast differentiation (44%), with 12% of genes sharing a common profile in both differentiation lineages.
Table S2, in [ 3], lists 13 groups of nuclear encoded genes, each group consisting of functionally related genes that share a common expression profile; the expression data or profile for genes in each group is also given.
Triptans, share a common pharmacological profile targeting to 5-HT1B/1D/1F 5-HT1B/1D/1Fth differeceptorsmacokinetic and pharmacodynamic properties resulting to slight diverse efficacy and safety that may be important for the treatment goals.
Interestingly, these anxiolytics and the antidepressant imipramine share a common expression profile and imipramine can act efficiently to reduce anxiety [ 57].
In addition, we compared the association in BCIS with 10,645 invasive BC cases to investigate whether the two types of disease share a common genetic profile or not.
Using unconditional logistic regression models adjusted for age and study, we estimated the association of SNPs with BCIS using two different comparison groups: healthy controls and invasive BC subjects to investigate whether BCIS and BC share a common genetic profile.
All chromosomes were seen to bear potential clusters (Additional file 4: Figure S3); however, closer examination revealed that genes within such clusters do not share a common expression profile, arguing against any functional organization and consistent with a previous study suggesting that P. falciparum lacks chromosomal domains with common expression profiles [ 1].
1 Recent findings from population-based studies indicate that suicidal thoughts and attempts are parts of a continuum and share a common risk profile. 2 3 It is well known from general population studies that anxiety and depression contribute to raised suicide risk, 4 6 yet some prospective studies have also linked anxiety and depression to increased incidence of suicidal thoughts.
Social insects use cuticular hydrocarbons to recognize ants from the same colony (Thomas et al. 1999; Wagner et al. 2000; Torres et al. 2007), and individuals within a colony often share a common hydrocarbon profile, or colony odor (Denis et al. 2006; Martin et al. 2008).
