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In mammals, our analysis detected positively selected (PS) sites in exposed regions in both TLR1 (286Q, 286Q Figure 3A) and TLR6 (296D Figure 3B) at similar regions (suggesting both regions are functionally important, and possibly share a common function) in or near the central domain but not in TLR2.
This approach is based on the commonly accepted assumption that orthologs genes derived by speciation are more likely to share a common function, in contrast to paralogs genes derived by gene duplication which are expected to diverge functionally over time [ 1, 2].
The activity of the cell is often coordinated by the organisation of proteins into regulatory circuits that share a common function.
When two or more components actually share a common function, they are described as actually redundant.
Potential redundancy implies that under the right circumstances, two or more components could share a common function.
Rather, the traits that evolved lower correlation are usually those that have different functions, and those more closely correlated the ones that share a common function (Olson and Miller 1958).
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For instance, every module has to be structurally dense and/or functionally coherent (i.e. every node in module shares a common function), the coverage of has to be high, and the amount of overlap between modules should be low.
Our results indicate that cHes6-1 shares a common function during neurogenesis with cHes6-2, both contributing to relieve differentiating neurons from Notch activity, although through different molecular mechanisms.
The closest functional and structural homologue of RbbA is elongation factor EF-3 of Saccharomyces cerevisiae which shares a common function in translation and several sequence motifs such as an ELVES motif present in tRNA binding proteins, two "LSGGQ" ATP binding motifs and two Walker motifs (ABC cassettes) that define this ABC class of transporters as the most abundant ATPases in all cells [38].
Additionally, some proteins, despite sharing a common function, are more diverse at the sequence level.
These studies showed that whilst relatives in most superfamilies shared a common function, in the most highly populated superfamilies considerable divergence of sequence and function had occurred.
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