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Ror RTKs share a common domain structure.
Both proteins share a common domain architecture with hydrophilic N-terminal and hydrophobic C-terminal regions.
These proteins share a common domain architecture and promote bacterial adhesion to host cells.
RbSTAT1 and RbSTAT1L were found to share a common domain architecture with mammalian STAT1.
They share a common domain architecture that features an N-terminal MIT (microtubule interacting and trafficking) domain followed by a single AAA ATPase cassette.
IL-12 and IL-23 share a common domain, p40, which is the target of the recently FDA-approved ustekinumab.
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Phylogenetic methods of ortholog identification have also been developed; these methods can be applied to protein data sets sharing a common domain architecture or which share a single functional domain but differ outside this region of homology.
In all species, TLR2 shared a common domain architecture: an extra-cellular domain containing 20 Leucine Rich Repeats between AA54 and AA584, a transmembrane domain at AA585 AA607 and an intracellular TIR domain at AA633 AA783.
All pacifastin members that have been identified at the molecular level are precursor peptides sharing a common domain organization; an N-terminal signal sequence followed by a variable number of inhibitor domains.
This risk is mitigated by the strong tendency for sequences sharing a common domain architecture to cluster closely on a phylogenetic tree, provided that the domain selected as the basis for the phylogenetic tree topology is sufficiently long.
The utility of domain annotation is that it allows researchers to quickly select all genes sharing a common domain; for example, selecting the 60 different sequences matching the domain COG5576 (homeodomain) retrieves putative homologs of 51 different genes with known roles in development and morphogenesis (e.g., SIX4, PAX3, dll, and engrailed).
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