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Consensus has been key to shaping the code.
Furthermore, these are the very amino acids for which the cognate triplets (anticodons and/or codons) occur more frequently in the aa-binding centers of RNA aptamers than expected by chance alone, thus suggesting that stereochemical affinity played a part in shaping the code [ 40- 42].
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Within this framework however, we saw selection shaping the coding repertoire of E.coli strains toward distinct ecotypes with different phenotypic properties.
More recent studies, however, challenge this view and convincingly show that mutational bias can also be a dominant force in shaping the coding capacity of plant organelles and especially of Poaceace plastomes [ 39, 40].
The obvious implication is that evolution and natural selection have shaped the code in some way.
But in itself, these significance tests do not pose any statement about the evolutionary mechanisms that shaped the code.
Their evolution is in itself puzzling [ 67, 68], but this specificity is what is thought to have shaped the code [ 6, 67, 68].
These data suggest that additional forces shape the coding sequences and oppose mutational bias, e.g. resulting in G|C enrichment despite background A|T enrichment.
On the other hand, the events shaping the genetic code took place long time ago, and due to the relative compactness of the extant genetic code, many alternative scenarios for its origin are conceivable (and have been put forward).
We thus suggest that transposons have not had a large role in shaping the protein coding genes of Coccidia and especially E. falciformis but potentially had a role in the emergence of the non-coding repeat repertoire.
Taken together, these results suggest the differential contributions of these sensory cues in shaping the hippocampal population code.
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