Sentence examples for shaping the active from inspiring English sources

In general additional modules fused to a catalytic domain may play a role in substrate specificity by providing a specific binding site or shaping the active site to recognize a substrate with a different shape or size [40].

Interestingly, this lysine appears to be important for shaping the active site as the enantioselective behavior of PAMO was found to be improved in the K336 mutant.

Overall, while all three clusters simultaneously encode specificity on different parts of the substrate peptide, by shaping the active site in a cumulative and non-linear fashion, cluster 1 appears to be the main driver of specificity.

The crystal structures of the CTX-M-14 S70G S237A:S237andand S70G S237A R276A mutants alone and in complex with cefotaxime revealed the importance of residues Ser237 and Arg276 in establishing the interactions with cefotaxime and cooperatively shaping the active site in the region of Asn170 and Asp240.

These residues shape the active site for the complementary ligand binding.

We proposed a plausible model demonstrating how Prp8 and Brr2 might collaborate to shape the active site of the spliceosome [ 11 ].

The loop contributes to the crevice shaping the entrance to the active site and, due to its strong interactions with the beginning of the C-terminal α-domain, plays a pivotal role for MCAD tetramerization.

Therefore the study underlines the role of climate in the time scales of 103 years in shaping the landscape of an active mountain like the Himalaya.

In this model men produced seed for conception while women furnished only matter in the form of the menstrual blood ('flowers') that was shaped by the active principal of the male seed to form the foetus, and which was also retained during pregnancy to provide nourishment to it in the womb during gestation.

He was active in shaping the lives of his sons Barry and Lloyd and his grandchildren Joseph, Bebe, Shayna and Ethan.

Amid the political melee, candidates dismiss the notion that the job they want will be anything but active in shaping the city's future.