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Our data provide evidence for experience-induced shaping of neural responses in ventral temporal cortex.
Furthermore, several other proteins can act as cues to promote self-avoidance and control the shaping of neural circuits (Fuerst et al., 2008; Matsuoka et al., 2012); could these molecules also be involved and could the same molecules have different roles in specific cell types?
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Neurulation is responsible for initial shaping of the central nervous system and formation of the neural tube, the precursor of the brain and spinal cord.
In addition, proNGF is believed to contribute to neuronal plasticity and neural connection shaping of the adult brain, a function that is likely mediated by the complementary ability of proNGF to promote apoptosis during development (for a review see [ 21]).
DCM for spontaneous fluctuations makes even less assumptions about the neural response and can capture different shapes of neural responses, e.g. mono- or biphasic.
Sex hormones may thus act as neuromodulators themselves, shaping the activity of neural networks on a relatively rapid time scale.
Exencephaly also occured in some of the Tfap2a mutants and we observed additional morphometric differences that indicate an influence of neural tube closure defects on facial shape.
Recent studies using this paradigm showed narrow shape tuning of neural populations in occipitotemporal cortex to sub-exemplar faces [31], [32] and trained car stimuli [16].
This study highlights the importance of neuromodulators in shaping local neural circuit activity to accommodate the internal physiological state of an organism.
Accordingly, with the idea that glia plays critical role in determining or sensing neuronal well-being and is capable of shaping neural activities either in healthy or in several pathological brain conditions [ 39– 41], our current findings demonstrate the occurrence of gliosis in the NTS of albumin-sensitized rats.
In the cortex, this activity shapes the connectivity of neural circuitry from which consciousness emerges.
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