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MGBD binding depends on the spine of hydration, van der Waal's interactions with the floor or walls of the minor groove, charge interactions between cationic drug groups and negative electrostatic sequences, the shapes of base pairs, and the width of the minor groove.
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This study identifies a new type of pausing mechanism, by which the RNAP core recognizes the shape of base pairs of the RNA DNA hybrid, which determines the rate of translocation and the nucleotide addition cycle.
They showed that the shape of the base analogue alone was not sufficient for base selectivity but that H-bonding was essential for proper primer extension and proofreading.
They have no legs; instead, they're built of what look like shiny, polka-dotted skirts about the size and shape of the base of an industrial-grade floor-waxing machine.
A more accurate picture was chosen, which showed the shape of the base of the sand.
Its soft tissue doesn't preserve in human fossils, but its lower position in our necks affects the shape of the base of our skulls.
We demonstrated that the shape of a base polymer film was controlled by a photo-pattering technique.
The workflow allows the modification of the initial shape of the Base Case by running iterative simulations through the Galapagos and Octopus evolutionary solvers.
The presence of major biases in the starting locations, or possibly the presence of sequencing primers left in the input data, could be responsible for the shape of the base call graph in Figure 1.
The inferior border was located at a well-defined distance from and approximated the average anatomical shape of the base of the skull.
The projection can be realized, e.g., with optical filters that modify sensor spectral sensitivity to match with the shape of a base vector.
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